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Chemistry of Hydrogen Peroxide Formation and Elimination in Mammalian Cells, and Its Role in Various Pathologies
The most common include: Genital yeast infections (more common in women) Urinary tract infections Increased urination or thirst Mild dehydration More serious risks, though less common, include: Ketoacidosis , even in the absence of high blood sugar Acute kidney injury , especially in volume-depleted patients Lower limb amputation risk , though more frequently reported with other SGLT2 inhibitors like canagliflozin To minimize these risks, patients should stay well-hydrated, maintain proper hygiene, and report unusual symptoms such as severe fatigue or nausea
Large or high-fat meals amplify gastric slowing
The practical solution: switch to transdermal HRT The simplest way to avoid the absorption problem is to use non-oral hormone delivery
Stidworthy, M
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